Fotagliptin

Fotagliptin is a pharmaceutical drug used in the treatment of type 2 diabetes. It belongs to the class of antidiabetic drugs known as dipeptidyl peptidase-4 inhibitors or DPP-4 inhibitors.

Mechanism of Action

Fotagliptin works by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4). This enzyme is involved in the breakdown of incretin hormones, which are released by the body during meals to stimulate the release of insulin. By inhibiting DPP-4, fotagliptin increases the levels of incretin hormones, leading to increased insulin release and decreased glucagon release. This results in lower blood glucose levels.

Uses

Fotagliptin is used in the management of type 2 diabetes. It is typically used in combination with diet and exercise to improve blood sugar control in adults with type 2 diabetes. Fotagliptin may be used alone or with other medications, including metformin or a sulfonylurea.

Side Effects

Common side effects of fotagliptin include nausea, diarrhea, and abdominal pain. Less common but more serious side effects can include pancreatitis and hypoglycemia.

Contraindications

Fotagliptin is contraindicated in patients with a history of hypersensitivity to fotagliptin or any of its components. It is also contraindicated in patients with type 1 diabetes or diabetic ketoacidosis.

See Also

• Dipeptidyl peptidase-4 inhibitors
• Type 2 diabetes
• Incretin
• Insulin
• Glucagon

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