Fotagliptin

Fotagliptin is a pharmaceutical drug used in the treatment of type 2 diabetes. It belongs to the class of antidiabetic drugs known as dipeptidyl peptidase-4 inhibitors or DPP-4 inhibitors.

Mechanism of Action[edit | edit source]

Fotagliptin works by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4). This enzyme is involved in the breakdown of incretin hormones, which are released by the body during meals to stimulate the release of insulin. By inhibiting DPP-4, fotagliptin increases the levels of incretin hormones, leading to increased insulin release and decreased glucagon release. This results in lower blood glucose levels.

Uses[edit | edit source]

Fotagliptin is used in the management of type 2 diabetes. It is typically used in combination with diet and exercise to improve blood sugar control in adults with type 2 diabetes. Fotagliptin may be used alone or with other medications, including metformin or a sulfonylurea.

Side Effects[edit | edit source]

Common side effects of fotagliptin include nausea, diarrhea, and abdominal pain. Less common but more serious side effects can include pancreatitis and hypoglycemia.

Contraindications[edit | edit source]

Fotagliptin is contraindicated in patients with a history of hypersensitivity to fotagliptin or any of its components. It is also contraindicated in patients with type 1 diabetes or diabetic ketoacidosis.