Free fatty acid receptor 1

Free fatty acid receptor 1 (FFAR1), also known as G protein-coupled receptor 40 (GPR40), is a protein that in humans is encoded by the FFAR1 gene. It is a member of the G protein-coupled receptor family and plays a significant role in the regulation of glucose homeostasis and insulin secretion.

Function

FFAR1 is a receptor for medium and long chain free fatty acids (FFAs). It is mainly expressed in pancreatic beta cells and to a lesser extent in the brain, where it mediates the potentiation of glucose-stimulated insulin secretion. FFAR1 is involved in the taste perception of fatty acids, and it also mediates the taste of fat.

Clinical significance

FFAR1 has been identified as a potential therapeutic target for the treatment of type 2 diabetes. Activation of FFAR1 by FFAs enhances insulin secretion from pancreatic beta cells only in the presence of elevated glucose levels. This glucose-dependent insulinotropic effect has led to the development of synthetic FFAR1 agonists for the treatment of type 2 diabetes.

Pharmacology

Several synthetic FFAR1 agonists have been developed for the treatment of type 2 diabetes. These include TAK-875 (Fasiglifam), a selective FFAR1 agonist that has been shown in clinical trials to improve glycemic control in patients with type 2 diabetes.

See also

• Free fatty acid receptor
• G protein-coupled receptor
• Type 2 diabetes
• Insulin
• Glucose

References

‎

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian