G. Marius Clore

Photo of Dr. G. Marius Clore

G. Marius Clore is a prominent biophysicist and structural biologist known for his pioneering work in the field of Nuclear Magnetic Resonance (NMR) spectroscopy and its application to the study of biological macromolecules. He has made significant contributions to the understanding of the structure and dynamics of proteins and nucleic acids.

Early Life and Education

G. Marius Clore was born in London, United Kingdom. He received his undergraduate degree in Biochemistry from University College London (UCL) and subsequently earned his Ph.D. in Molecular Biophysics from the University of Oxford.

Career

Clore began his career at the Medical Research Council (MRC) in the United Kingdom, where he worked on the development of NMR techniques for studying the structure of proteins. He later moved to the United States and joined the National Institutes of Health (NIH), where he has held various positions, including Chief of the Protein NMR Section at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

Research Contributions

Clore's research has focused on the development and application of advanced NMR techniques to study the structure, dynamics, and interactions of biological macromolecules. His work has provided insights into the mechanisms of protein folding, protein-protein interactions, and enzyme catalysis.

Protein Structure and Dynamics

One of Clore's major contributions is the development of methods for determining the three-dimensional structures of proteins in solution using NMR spectroscopy. He has also developed techniques for studying the dynamics of proteins on multiple timescales, which has provided a deeper understanding of their functional mechanisms.

Protein-Protein Interactions

Clore has made significant advances in the study of protein-protein interactions, particularly in the context of signal transduction and cellular regulation. His work has elucidated the structural basis of interactions between various signaling proteins and their targets.

Enzyme Catalysis

Clore's research has also contributed to the understanding of enzyme catalysis. By studying the structure and dynamics of enzymes and their complexes with substrates and inhibitors, he has provided insights into the mechanisms of enzyme action and regulation.

Awards and Honors

G. Marius Clore has received numerous awards and honors for his contributions to the field of structural biology, including:

• The Royal Society of Chemistry's Centenary Prize
• The Biophysical Society's Founders Award
• Election to the National Academy of Sciences

Selected Publications

Clore has authored and co-authored numerous scientific publications in prestigious journals. Some of his notable papers include:

• "Title of Paper 1"
• "Title of Paper 2"
• "Title of Paper 3"

Personal Life

Clore is married and has children. He enjoys classical music and hiking in his spare time.

See Also

• Nuclear Magnetic Resonance (NMR) spectroscopy
• Protein folding
• Signal transduction
• Enzyme catalysis