GLUT2

GLUT2 or Glucose transporter type 2 is a protein that in humans is encoded by the SLC2A2 gene. It is one of the several glucose transporter types that facilitate glucose movement across the cell membrane.

Function

GLUT2 is a member of the solute carrier family which are membrane transport proteins. It is a high-capacity, low-affinity glucose transporter, responsible for glucose transport into the cell. It is found in the cell membrane of hepatocytes (liver cells), beta cells of the pancreas, kidney tubules, small intestine enterocytes, and certain brain neurons.

In the pancreas, GLUT2 is involved in the regulation of insulin, and in the brain, it is involved in the regulation of energy homeostasis.

Clinical significance

Mutations in the SLC2A2 gene are associated with Fanconi-Bickel syndrome, a rare inherited disorder characterized by the body's inability to properly process certain sugars and proteins.

See also

• Glucose transporter
• Solute carrier family
• Fanconi-Bickel syndrome

References

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