Germinal matrix hemorrhage

Germinal Matrix Hemorrhage (GMH) is a type of intracranial hemorrhage that occurs in the brain of premature infants. This condition is characterized by bleeding into the germinal matrix, a highly vascularized area in the brain where neuronal and glial cell proliferation occurs.

Etiology

The primary cause of GMH is the fragility of the blood vessels in the germinal matrix. Other contributing factors include fluctuations in cerebral blood flow, hypoxia, and coagulation abnormalities. Premature infants, especially those born before 32 weeks of gestation, are at a higher risk due to the underdevelopment of their blood vessels.

Pathophysiology

The germinal matrix is a site of rapid cell proliferation and is rich in blood vessels. These vessels are fragile and prone to rupture, leading to hemorrhage. The hemorrhage can extend into the ventricles, causing intraventricular hemorrhage (IVH), which can lead to hydrocephalus and other complications.

Clinical Presentation

Infants with GMH may present with a variety of symptoms, including apnea, changes in muscle tone, seizures, and a bulging fontanelle. The severity of symptoms often correlates with the extent of the hemorrhage.

Diagnosis

Diagnosis of GMH is typically made through ultrasound imaging of the brain, which can detect the presence and extent of the hemorrhage. Other diagnostic tools may include magnetic resonance imaging (MRI) and computed tomography (CT) scans.

Treatment and Prognosis

Treatment for GMH primarily involves supportive care and management of symptoms. In severe cases, surgical intervention may be necessary to relieve pressure on the brain. The prognosis for infants with GMH varies widely, depending on the severity of the hemorrhage and the presence of other complications.

See Also

• Intracranial hemorrhage
• Intraventricular hemorrhage
• Premature birth
• Neonatology