Glomeruloid hemangioma

Glomeruloid hemangioma is a rare type of skin lesion that is often associated with the POEMS syndrome. It is characterized by its unique appearance under the microscope, resembling a glomerulus, a structure found in the kidney.

Clinical Presentation

Patients with glomeruloid hemangioma typically present with multiple, small, red to purple papules on the skin. These lesions are often found on the trunk and extremities. They are usually asymptomatic, but can sometimes cause discomfort or bleeding.

Pathology

Under the microscope, glomeruloid hemangiomas have a unique appearance. They are composed of small, rounded clusters of blood vessels that resemble glomeruli, the filtering units of the kidney. These vessels are often surrounded by a layer of pericytes, a type of cell that supports the blood vessels.

Association with POEMS Syndrome

Glomeruloid hemangioma is often associated with POEMS syndrome, a rare disorder characterized by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes. The presence of glomeruloid hemangioma in a patient can be a clue to the diagnosis of POEMS syndrome.

Treatment

The treatment of glomeruloid hemangioma is primarily aimed at managing the underlying POEMS syndrome. This can involve a combination of therapies, including chemotherapy, radiation therapy, and stem cell transplantation. In some cases, the skin lesions may be removed surgically for cosmetic reasons or to relieve symptoms.

See Also

• POEMS syndrome
• Hemangioma
• Skin lesion

References

Glomeruloid hemangioma Resources
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