Granulocyte colony stimulating factor

Granulocyte Colony-Stimulating Factor (G-CSF) is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. It is produced by endothelium, macrophages, and a number of other immune cells. The pharmaceutical analogs of naturally occurring G-CSF are called colony-stimulating factors.

Function

G-CSF stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. It is a part of the immune/inflammatory cascade, responding to infection and inflammation in the body.

Medical Use

G-CSF is used medically to treat neutropenia, a condition where the body does not have enough neutrophils, often a side-effect of chemotherapy. It is also used in stem cell transplantation.

Side Effects

Common side effects include bone pain and flu-like symptoms. More serious side effects may include spleen rupture and allergic reactions.

See Also

• Neutropenia
• Chemotherapy
• Stem cell transplantation

References

Granulocyte colony stimulating factor Resources
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