Granulocyte macrophage colony-stimulating factor receptor

Granulocyte macrophage colony-stimulating factor receptor (GM-CSFR) is a protein that in humans is encoded by the CSF2RA gene. This receptor is a part of the cytokine receptor family, specifically the type I cytokine receptors. It is involved in the process of cell signaling and plays a crucial role in the immune response.

Structure

The GM-CSFR is a heterodimeric protein complex that consists of two different subunits: an alpha (α) subunit and a beta (β) subunit. The α subunit is specific to the GM-CSFR, while the β subunit is shared with other cytokine receptors, such as the IL-3 receptor and the IL-5 receptor.

Function

The primary function of the GM-CSFR is to bind the granulocyte macrophage colony-stimulating factor (GM-CSF). This binding initiates a series of signal transduction events that lead to the proliferation, differentiation, and survival of hematopoietic cells. The GM-CSFR is expressed on the surface of several cell types, including granulocytes, macrophages, and dendritic cells.

Clinical significance

Mutations in the CSF2RA gene that encodes the GM-CSFR can lead to pulmonary alveolar proteinosis, a rare lung disease. Additionally, the overexpression of GM-CSF and its receptor has been associated with several types of cancer, including leukemia and lung cancer.

See also

• Cytokine receptor
• Granulocyte-macrophage colony-stimulating factor
• Pulmonary alveolar proteinosis

References

‎

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian