Grb2 associated binding protein 3

Grb2 associated binding protein 3 (Gab3) is a protein that in humans is encoded by the GAB3 gene. It is a member of the Grb2-associated binder family, which plays a crucial role in cell signaling and cell growth.

Function

Gab3 is a member of the Gab protein family. Gab proteins have been implicated in a variety of biological processes, including cell proliferation, cell differentiation, and cell migration. They act as docking proteins, linking receptor tyrosine kinases to downstream signaling pathways.

Gab3 specifically has been shown to play a role in platelet-derived growth factor signaling, and may also be involved in other signaling pathways. It is expressed in a variety of tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.

Structure

The GAB3 gene is located on the 1st chromosome, with its specific location being 1q23.3. The gene contains 1 exon. Gab3 protein is a single-pass type I membrane protein, and it contains one PH domain and two SH3 domains.

Clinical significance

While the exact role of Gab3 in disease is not fully understood, it is thought to play a role in certain types of cancer, due to its involvement in cell signaling and growth. Further research is needed to fully understand the implications of Gab3 in human health and disease.

See also

• Grb2-associated binder
• Cell signaling
• Receptor tyrosine kinase