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Guanadrel Sulfate is a pharmacological agent that is primarily used as an antihypertensive medication. It belongs to the class of drugs known as sympatholytics, which work by inhibiting the function of the sympathetic nervous system to lower blood pressure.

Mechanism of Action

Guanadrel Sulfate works by blocking the release of norepinephrine, a neurotransmitter that is responsible for the constriction of blood vessels. By inhibiting the release of norepinephrine, Guanadrel Sulfate allows the blood vessels to relax and dilate, thereby reducing blood pressure.

Uses

Guanadrel Sulfate is primarily used in the treatment of hypertension. It may be used alone or in combination with other antihypertensive medications. It is also sometimes used in the management of pheochromocytoma, a rare tumor of the adrenal glands that can cause high blood pressure.

Side Effects

Like all medications, Guanadrel Sulfate can cause side effects. Common side effects include dizziness, fatigue, and orthostatic hypotension. Less common side effects can include sexual dysfunction, depression, and anxiety.

Contraindications

Guanadrel Sulfate is contraindicated in patients with a known hypersensitivity to the drug. It should also be used with caution in patients with severe coronary artery disease, heart failure, or renal impairment.

Drug Interactions

Guanadrel Sulfate can interact with a number of other medications, including other antihypertensive drugs, tricyclic antidepressants, and monoamine oxidase inhibitors.

Dosage and Administration

The dosage of Guanadrel Sulfate is individualized based on the patient's response to treatment. It is typically started at a low dose and gradually increased until the desired blood pressure control is achieved.

See Also

• Antihypertensive drugs
• Sympatholytics
• Hypertension
• Pheochromocytoma