HCN2

HCN2 or Hyperpolarization-activated cyclic nucleotide-gated channel 2 is a protein that in humans is encoded by the HCN2 gene. This protein is a member of the family of potassium channels and is widely expressed in the heart and central nervous system.

Function

HCN2 is a member of the family of hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels. HCN channels are integral membrane proteins that serve as nonselective cation channels, allowing the flow of sodium and potassium ions. They are activated by a hyperpolarization potential and are permeable to the monovalent cations K+ and Na+.

Clinical significance

Mutations in the HCN2 gene have been associated with various medical conditions, including epilepsy, chronic pain, and cardiac arrhythmia. Research is ongoing to understand the role of HCN2 in these conditions and to develop potential treatments.

See also

• HCN1
• HCN3
• HCN4

External links

• GeneCards - HCN2