HCN4

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HCN4 is a gene that encodes the protein known as Hyperpolarization activated cyclic nucleotide gated potassium channel 4. This protein is a member of the potassium channel family and is predominantly expressed in the heart, where it plays a crucial role in regulating the heart's electrical activity.

Function[edit | edit source]

The HCN4 gene provides instructions for making a protein that is part of ion channels, which are complex proteins that control the flow of ions into and out of cells. Specifically, the HCN4 protein forms channels that transport positively charged potassium ions out of cells and is involved in the generation and conduction of electrical signals within the heart. These signals control the heart's rhythmic contractions.

Clinical significance[edit | edit source]

Mutations in the HCN4 gene have been associated with a variety of cardiac disorders, including Sick sinus syndrome, Brugada syndrome, and Atrial fibrillation. These conditions can lead to symptoms such as palpitations, dizziness, fainting, and sudden death.

Research[edit | edit source]

Research into the HCN4 gene and its associated protein continues to be a significant focus in the field of cardiology. Understanding the role of this gene in heart function and disease could lead to the development of new treatments for cardiac disorders.

See also[edit | edit source]

References[edit | edit source]


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