HLA-B38

HLA-B38 is a human leukocyte antigen serotype within the HLA-B serotype group. The serotype is determined by the antibody recognition of antigen B38. This serotype is a split antigen of the broad antigen HLA-B16, and it is commonly found in populations in West Africa, Spain, and Portugal.

Function

HLA-B38 is a protein that in humans is encoded by the HLA-B gene. The protein encoded by this gene is a member of the major histocompatibility complex (MHC) class I molecules, which are responsible for the presentation of foreign antigens to the immune system. This protein plays a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen.

Clinical significance

HLA-B38 has been associated with various diseases, including rheumatoid arthritis, ankylosing spondylitis, and Behcet's disease. It is also associated with a higher risk of HIV progression.

Distribution

HLA-B38 is commonly found in populations in West Africa, Spain, and Portugal. It is also found in lower frequencies in other populations around the world.

See also

• HLA-B
• Human leukocyte antigen
• Major histocompatibility complex
• Antigen presentation

References

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