HLA-DQ6

HLA-DQ6 is a human leukocyte antigen (HLA) serotype within the HLA-DQ (DQ) class II histocompatibility complex. The HLA-DQ6 serotype is determined by the presence of the DQA1*0102 and DQB1*0602 alleles. This serotype is associated with several autoimmune diseases and is an important factor in transplantation immunology.

Structure

HLA-DQ6 is a heterodimer composed of an alpha (DQA1) and a beta (DQB1) chain. The alpha chain is encoded by the DQA1 gene, and the beta chain is encoded by the DQB1 gene. The specific alleles that form HLA-DQ6 are DQA1*0102 and DQB1*0602.

Function

The primary function of HLA-DQ6, like other HLA class II molecules, is to present antigenic peptides to CD4+ T cells. This process is crucial for the activation of the adaptive immune system and the initiation of an immune response.

Disease Associations

HLA-DQ6 has been implicated in several autoimmune diseases, including:

• Multiple sclerosis
• Narcolepsy
• Systemic lupus erythematosus

Transplantation

In the context of organ transplantation, HLA-DQ6 typing is important for matching donors and recipients to reduce the risk of graft rejection and improve transplant outcomes.

Genetics

The genes encoding the HLA-DQ6 heterodimer are located on the short arm of chromosome 6 (6p21.3). The DQA1*0102 and DQB1*0602 alleles are inherited together as a haplotype.

See Also

• HLA-DQ
• HLA-DQ2
• HLA-DQ8
• HLA-DQ9
• HLA-DQ5