HLA-DR11

HLA-DR11 is a human leukocyte antigen serotype within the HLA-DR serotype group. The serotype is determined by the antibody recognition of β11 subset of HLA-DR β-chains. The β-chain of HLA-DR is a polymorphic gene product; 3 genes, DRB1, DRB3, DRB4 and DRB5, encode most of the HLA-DR β-chains. This group's serotype can react with cells from individuals who have the HLA-DR11 gene.

Function

HLA-DR is a MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).

Disease Association

HLA-DR11 has been associated with a number of autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. It is also associated with a decreased risk of type 1 diabetes.

Alleles

HLA-DR11 is an allele group that contains many individual alleles, or variations, of the HLA-DRB1 gene. These alleles can be further divided into subtypes, such as HLA-DRB1*11:01, HLA-DRB1*11:02, and so on.

See Also

• HLA-DR
• Human leukocyte antigen
• MHC class II