HLA-DR7

HLA-DR7 is a human leukocyte antigen serotype within the HLA-DR serotype group. The serotype is determined by the antibody recognition of β-subunit of HLA-DR. This β-subunit is encoded by the HLA-DRB1 gene. HLA-DR7 is associated with several autoimmune diseases and infectious diseases.

Structure and Function

HLA-DR7 is a cell surface glycoprotein involved in the immune system's regulation. It presents peptides derived from extracellular proteins to the T cells, which are crucial for the immune response. The HLA-DR7 molecule is a heterodimer consisting of an α (DRA) and a β chain (DRB), both anchored in the membrane.

Disease Associations

HLA-DR7 has been associated with several diseases, including:

• Rheumatoid arthritis: Studies have shown a significant association between HLA-DR7 and rheumatoid arthritis, particularly in certain ethnic groups.
• Coeliac disease: HLA-DR7 is one of the HLA types associated with coeliac disease.
• Hepatitis B: HLA-DR7 has been associated with chronic hepatitis B infection and the development of hepatocellular carcinoma.

Genetic Linkage

HLA-DR7 is linked to other HLA serotypes due to its location on chromosome 6. This linkage is important in understanding the genetic predisposition to diseases.

See Also

• HLA-DR
• Human leukocyte antigen
• Autoimmune diseases
• Infectious diseases

References

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