HLA-DR8

HLA-DR8 is a human leukocyte antigen serotype within the HLA-DR serotype group. The serotype is determined by the antibody recognition of β-subunit of HLA-DR. This β-subunit is encoded by HLA-DRB1 gene and HLA-DR8 is a split antigen of the broad antigen HLA-DR3. HLA-DR8 and HLA-DR53 are almost always co-expressed.

Function

HLA-DR is a cell surface receptor involved in regulating the immune system. It plays a crucial role in the immune response by presenting peptides derived from extracellular proteins to T cells, a type of white blood cell that plays a central role in cell-mediated immunity.

Association with Diseases

HLA-DR8 has been associated with several autoimmune and infectious diseases. These include rheumatoid arthritis, multiple sclerosis, type 1 diabetes, and hepatitis B infection. However, the exact role of HLA-DR8 in these diseases is not fully understood and is the subject of ongoing research.

Distribution

HLA-DR8 is found at highest frequencies in populations in the Middle East and North Africa. It is also found at significant frequencies in populations in Southern Europe and East Asia.

See Also

• HLA-DR
• HLA-DRB1
• Human leukocyte antigen