HOXA11

From WikiMD.com - Food, Medicine & Wellness Encyclopedia

HOXA11 is a gene that belongs to the homeobox family of genes. The protein encoded by this gene is a transcription factor that plays a crucial role in the development of the limbs and reproductive system.

Structure[edit | edit source]

The HOXA11 gene is located on the short (p) arm of chromosome 7 at position 15.2. It spans approximately 27 kilobases and consists of two exons. The encoded protein is 410 amino acids long and contains a homeobox DNA-binding domain.

Function[edit | edit source]

HOXA11 is involved in the regulation of gene expression, morphogenesis, and differentiation. It is essential for the proper development of the limbs and the reproductive system. In the limbs, HOXA11 is required for the formation of the radius and ulna in the forelimb and the tibia and fibula in the hindlimb. In the reproductive system, it is necessary for the development of the uterus and cervix in females and the vas deferens in males.

Clinical significance[edit | edit source]

Mutations in the HOXA11 gene have been associated with Hand-foot-genital syndrome, a rare disorder characterized by limb malformations and urogenital defects. Additionally, abnormal expression of HOXA11 has been implicated in several types of cancer, including endometrial cancer and ovarian cancer.

See also[edit | edit source]

References[edit | edit source]


Stub icon
   This article is a medical stub. You can help WikiMD by expanding it!



WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Transform your life with W8MD's budget GLP1 injections from $125

W8mdlogo.png
W8MD weight loss doctors team

W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.

Why choose W8MD?

Book Your Appointment

Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD