HOXB5

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HOXB5 is a gene that belongs to the homeobox family of genes. The protein encoded by this gene is a transcription factor that plays a crucial role in embryonic development and cell differentiation.

Function[edit | edit source]

The HOXB5 gene is part of the HOX gene family, which is a group of genes that play a vital role in the development of the body plan of an organism. The HOXB5 gene, in particular, is involved in the development of the respiratory system and the central nervous system. It is also implicated in the development of certain types of cancer.

Structure[edit | edit source]

The HOXB5 gene is located on the long (q) arm of chromosome 17 at position 21.32. It spans about 3.2 kilobases and consists of two exons. The encoded protein is 253 amino acids long.

Clinical Significance[edit | edit source]

Mutations in the HOXB5 gene have been associated with various diseases. For instance, it has been linked to lung cancer, breast cancer, and leukemia. Studies have shown that the overexpression of HOXB5 can lead to the proliferation of cancer cells, suggesting that it may act as an oncogene.

Research[edit | edit source]

Research on the HOXB5 gene is ongoing, with scientists aiming to understand its exact role in development and disease. This could potentially lead to the development of new therapeutic strategies for diseases associated with this gene.


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