HOXC6

HOXC6 is a gene that in humans encodes the homeobox protein Hox-C6. The protein belongs to the antennapedia class of homeodomain proteins, which are critical for the regulation of gene expression, morphogenesis, and differentiation during embryonic development.

Structure

The HOXC6 gene is located on the long (q) arm of chromosome 12 at position 13. The gene spans approximately 26.6 kilobases and consists of two exons. The encoded protein is 284 amino acids in length and contains a homeobox DNA-binding domain.

Function

HOXC6 is part of the HOX gene family, a group of genes that play a crucial role in body layout and physical development in the womb. These genes are involved in the formation of tissues and organs during embryonic development. They are also responsible for the normal development of the limbs, spine, and other structures.

Clinical Significance

Alterations in the expression of the HOXC6 gene have been associated with several types of cancer, including prostate cancer, breast cancer, and lung cancer. Overexpression of HOXC6 has been found in these cancers and is often associated with a poor prognosis.

Research

Research is ongoing to understand the role of HOXC6 in cancer development and progression. Studies are also being conducted to explore the potential of HOXC6 as a therapeutic target in cancer treatment.

See Also

• Homeobox
• HOX gene
• Chromosome 12