HOXD12

HOXD12 is a gene that belongs to the homeobox gene family. The proteins encoded by these genes are known as transcription factors, which are crucial for the regulation of gene expression during embryonic development.

Function

The HOXD12 gene is part of the HOXD gene cluster, which is located on the short arm of chromosome 2. This gene cluster is one of four similar clusters that are found in the human genome. The HOXD12 gene, like other homeobox genes, plays a critical role in body plan and limb development. It is involved in the formation of digits and the anterior-posterior patterning in embryonic development.

Clinical Significance

Mutations in the HOXD12 gene have been associated with several medical conditions. For instance, it has been linked to synpolydactyly, a congenital condition characterized by the fusion of digits and the presence of extra digits. Research is ongoing to further understand the role of HOXD12 in human health and disease.

Research

The HOXD12 gene is a subject of intense research in the field of developmental biology. Studies are being conducted to understand its role in limb development and its potential involvement in various diseases.

See Also

• Homeobox
• HOXD
• Transcription factor
• Chromosome 2
• Synpolydactyly