HS 578T

HS 578T is a cell line derived from a human breast cancer tumor. It was first established in 1977 by Cailleau et al., and has since been widely used in cancer research to study the biology and treatment of breast cancer.

History

The HS 578T cell line was established from the pleural effusion of a 74-year-old female patient with metastatic breast cancer. The cells were cultured in vitro and have been maintained for over 40 years. The cell line is named after the initials of the patient from whom it was derived.

Characteristics

HS 578T cells are epithelial in nature and exhibit a high degree of pleomorphism, or variation in size and shape. They are triple-negative breast cancer (TNBC) cells, meaning they do not express estrogen receptor (ER), progesterone receptor (PR), or HER2/neu.

Use in Research

HS 578T cells are used in a variety of research applications, including the study of cell proliferation, cell migration, cell invasion, and drug resistance. They are also used to investigate the molecular mechanisms underlying breast cancer progression and to test potential therapeutic agents.

Genomic Profile

The HS 578T cell line has a complex karyotype, with numerous chromosomal aberrations. It is hypodiploid, meaning it has fewer than the normal number of chromosomes. The cell line also has mutations in several key cancer-related genes, including TP53 and PIK3CA.

References

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