Diphenylpyraline

Diphenylpyraline (also known as DPP or Hispril) is a first-generation antihistamine with anticholinergic properties. It is used primarily to treat allergic reactions and common cold symptoms.

Pharmacology

Diphenylpyraline is a H1 receptor antagonist, which means it works by blocking the action of histamine, a substance in the body that causes allergic symptoms. It is a member of the ethanolamine class of antihistaminergic agents.

Medical uses

Diphenylpyraline is used to relieve red, irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. It is also used to relieve the symptoms of urticaria (hives).

Side effects

Like other first-generation antihistamines, diphenylpyraline can cause a variety of side effects, including drowsiness, dizziness, dry mouth/nose/throat, headache, upset stomach, constipation, or trouble sleeping.

Contraindications

Diphenylpyraline should not be used in patients with hypersensitivity to diphenylpyraline or other antihistamines of similar chemical structure. It is also contraindicated in patients with narrow-angle glaucoma, peptic ulcer, prostatic hypertrophy, and bladder neck obstruction.

See also

• Antihistamine
• Histamine H1 receptor