Histatin

Histatin is a type of protein that is found in saliva. It is part of the antimicrobial peptide family, which means it helps to protect the body from harmful microorganisms. Histatins are produced by the parotid gland and the submandibular gland, two of the major salivary glands in the body.

Function

Histatins have several important functions in the body. They are primarily known for their antimicrobial properties, which help to protect the oral cavity from infection. They do this by disrupting the cell membrane of harmful microorganisms, causing them to die. In addition to their antimicrobial properties, histatins also play a role in wound healing. They promote the migration of epithelial cells, which helps to speed up the healing process.

Structure

Histatins are small proteins, typically consisting of between 7 and 38 amino acids. They are rich in histidine, an amino acid that gives them their name. Histatins are cationic, which means they carry a positive charge. This allows them to bind to the negatively charged cell membranes of microorganisms.

Clinical significance

Histatins may have potential applications in the treatment of various medical conditions. For example, they could be used to develop new antibiotics or antifungal drugs. They may also have potential in the treatment of oral diseases, such as periodontitis and oral candidiasis.

See also

• Antimicrobial peptides
• Saliva
• Oral cavity

Histatin Resources
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