Homprenorphine

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Homprenorphine

Homprenorphine is a semi-synthetic opioid that is derived from thebaine, a constituent of the opium poppy. It is used in the treatment of moderate to severe pain, and is also used in the treatment of opioid addiction. Homprenorphine is a partial agonist at the mu-opioid receptor, and an antagonist at the kappa-opioid receptor.

Pharmacology

Homprenorphine's pharmacological effects are due to its activity at the mu-opioid receptor, where it acts as a partial agonist. This means that while it can produce effects similar to those of full agonists such as morphine, its effects are limited by a ceiling effect. This can result in a lower risk of side effects such as respiratory depression.

At the kappa-opioid receptor, homprenorphine acts as an antagonist. This can result in a reduction in the dysphoric effects that can be associated with the use of other opioids.

Clinical Use

Homprenorphine is used in the treatment of moderate to severe pain. It can be used in both acute and chronic pain conditions. In addition to its use in pain management, homprenorphine is also used in the treatment of opioid addiction. It can help to reduce the symptoms of opioid withdrawal, and can also help to reduce the cravings for opioids that can occur in those with an addiction.

Side Effects

The side effects of homprenorphine can include nausea, vomiting, constipation, and drowsiness. It can also cause respiratory depression, although the risk of this is lower than with full opioid agonists. Other potential side effects can include itching, sweating, and dry mouth.

See Also

• Opioid
• Thebaine
• Mu-opioid receptor
• Kappa-opioid receptor