Opioid withdrawal

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Editor-In-Chief: Prab R Tumpati, MD
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Opioid withdrawal
Suboxone.jpg
Synonyms N/A
Pronounce N/A
Specialty N/A
Symptoms Anxiety, muscle pain, insomnia, sweating, nausea, vomiting, diarrhea, dilated pupils, yawning
Complications Dehydration, electrolyte imbalance, relapse
Onset Within hours to days after last opioid use
Duration Typically 5 to 10 days
Types Acute withdrawal, protracted withdrawal
Causes Cessation of opioid use after dependence
Risks Long-term opioid use, high-dose opioid use
Diagnosis Based on clinical presentation and history of opioid use
Differential diagnosis Other substance withdrawal, anxiety disorders, gastroenteritis
Prevention Gradual tapering of opioids, medication-assisted treatment
Treatment Supportive care, medications such as buprenorphine, methadone, clonidine
Medication Buprenorphine, methadone, clonidine
Prognosis Generally good with treatment, risk of relapse
Frequency Common among individuals with opioid use disorder
Deaths N/A


Opioid withdrawal is a severe physical condition caused by the abrupt cessation or reduction of prolonged use of opioids. Opioids are a class of drugs that include the illegal drug heroin, synthetic opioids such as fentanyl, and pain relievers available legally by prescription, such as oxycodone (OxyContin®), hydrocodone (Vicodin®), codeine, morphine, and many others.

Symptoms[edit | edit source]

Opioid withdrawal symptoms can range from mild to severe and may include:

  • Restlessness
  • Lacrimation (tearing) or rhinorrhea (runny nose)
  • Yawning
  • Perspiration or gooseflesh
  • Dilated pupils
  • Sleep difficulties
  • Increased heart rate
  • Nausea or vomiting
  • Diarrhea
  • Bone or joint aches
  • Mental health problems such as depression or anxiety

Causes[edit | edit source]

Opioid withdrawal is caused by the sudden cessation or reduction of prolonged use of opioids. The body becomes used to having opioids in the system, so when the drugs are no longer present, withdrawal symptoms can start.

Treatment[edit | edit source]

Treatment for opioid withdrawal includes medications and support. Medications can help to reduce the physical symptoms of withdrawal. Supportive care can help a person to cope with the physical discomfort and intense craving that characterize withdrawal.

Gallery[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

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Contributors: Prab R. Tumpati, MD