IGFBP1

IGFBP1 (Insulin-like Growth Factor Binding Protein 1) is a protein that in humans is encoded by the IGFBP1 gene. It is one of six binding proteins (IGFBP1-6) that have high affinity for Insulin-like Growth Factors (IGFs).

Function

IGFBP1 is a secreted protein that binds to both IGF-I and IGF-II with high affinity. The binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP1 is expressed in many tissues, including liver, brain, heart, and kidneys. It plays a crucial role in regulating IGF bioavailability, and thus, cell growth and survival.

Clinical Significance

Alterations in the serum concentration of IGFBP1 have been associated with a variety of diseases. High levels of IGFBP1 have been observed in conditions such as Type 1 Diabetes, Fasting, and Physical Exercise. Conversely, low levels of IGFBP1 are associated with Type 2 Diabetes, Insulin Resistance, and Obesity.

In addition, IGFBP1 has been implicated in the development and progression of several types of cancer, including Breast Cancer, Prostate Cancer, and Colorectal Cancer. It is thought that IGFBP1 may influence cancer cell growth and survival by modulating the bioavailability of IGFs.

Research

Research into IGFBP1 has focused on understanding its role in health and disease, and its potential as a therapeutic target. Studies have investigated the regulation of IGFBP1 expression, its interaction with IGFs and IGF receptors, and its effects on cell growth and survival.

See Also

• Insulin-like Growth Factor
• Insulin-like Growth Factor 1
• Insulin-like Growth Factor 2
• Insulin Resistance
• Type 1 Diabetes
• Type 2 Diabetes
• Breast Cancer
• Prostate Cancer
• Colorectal Cancer