IL17B
| IGSF2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ? | ||||||
| NCBI gene | 9398 | ||||||
| HGNC | 6080 | ||||||
| OMIM | 606662 | ||||||
| RefSeq | NM_005534 | ||||||
| UniProt | Q93033 | ||||||
| |||||||
IGSF2 (Immunoglobulin Superfamily Member 2), also known as CD101, is a protein encoded by the IGSF2 gene in humans. This protein is a member of the immunoglobulin superfamily, which is characterized by the presence of immunoglobulin-like domains.
Structure[edit | edit source]
IGSF2 is a type I transmembrane protein that contains multiple immunoglobulin-like domains. These domains are involved in protein-protein interactions and are crucial for the protein's role in the immune system. The extracellular region of IGSF2 is composed of several Ig-like domains, which are typical of proteins involved in cell adhesion and immune response.
Function[edit | edit source]
IGSF2 plays a significant role in the immune system. It is expressed on the surface of various immune cells, including T cells, B cells, and dendritic cells. The protein is involved in the regulation of immune responses, particularly in the modulation of T cell activation and proliferation. IGSF2 has been implicated in the suppression of T cell responses, which suggests a role in maintaining immune homeostasis and preventing autoimmunity.
Clinical Significance[edit | edit source]
Alterations in the expression or function of IGSF2 have been associated with various immune-related disorders. For instance, changes in IGSF2 expression have been observed in autoimmune diseases, where the regulation of T cell activity is disrupted. Additionally, IGSF2 may play a role in the immune evasion mechanisms of certain cancers, where its expression can influence the tumor microenvironment and immune surveillance.
Research Directions[edit | edit source]
Current research on IGSF2 is focused on understanding its precise role in immune regulation and its potential as a therapeutic target. Studies are exploring how modulation of IGSF2 activity could be used to enhance immune responses against tumors or to suppress unwanted immune activity in autoimmune diseases.
Also see[edit | edit source]
| IL17B | |
|---|---|
| Identifiers | |
| Symbol | ? |
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