ING1

ING1 or Inhibitor of Growth 1 is a protein that in humans is encoded by the ING1 gene. This protein is a tumor suppressor that can inhibit cell growth and cell cycle progression, and induce apoptosis.

Function

The ING1 protein is a member of the ING family of phosphatidyl inositol binding proteins. It has been implicated in various cellular processes including cell cycle regulation, DNA repair, apoptosis and senescence. ING1 is known to physically interact with the tumor suppressor protein p53, and is a part of the p53 transcriptional activation complex.

Clinical significance

Alterations in the ING1 gene have been associated with various types of cancer, including breast cancer, melanoma, and head and neck cancer. Studies have shown that the expression of ING1 is often reduced in cancerous tissues, suggesting a role for this protein in tumor suppression.

Research

Research into the function and potential therapeutic applications of ING1 is ongoing. Studies are investigating the role of ING1 in cellular senescence, a state of permanent cell cycle arrest that is thought to contribute to aging and cancer.

See also

• ING2
• ING3
• ING4
• ING5

External links

• ING1 at the National Center for Biotechnology Information