Icariin

Icariin is a chemical compound classified as a prenylated flavonol glycoside, a type of flavonoid. It is the 8-prenyl derivative of kaempferol 3,7-O-diglucoside. The compound has been isolated from several species of plants belonging to the genus Epimedium which are commonly known as Horny Goat Weed or Yin Yang Huo. Extracts from these plants are reputed to produce aphrodisiac effects, and are commonly used in Traditional Chinese Medicine to enhance erectile function, as well as for several other indications.

History

The use of Epimedium as a medicinal herb dates back to at least 400 A.D., where it has been used as a tonic for the reproductive system (boosting libido and treating impotence) and as a rejuvenating tonic (to relieve fatigue).

Pharmacology

Icariin is a PDE5 inhibitor, like sildenafil, the active compound in Viagra. It is also found to increase circulating testosterone levels in rats. It is a weak PDE5 inhibitor in vitro and to enhance the production of nitric oxide, as well as mimicking the effects of testosterone in rats.

Research

Preliminary studies have found that icariin can inhibit the activity of PDE5, a chemical that breaks down the compound nitric oxide, which plays a significant role in erectile function.

See also

• Epimedium
• PDE5 inhibitor
• Sildenafil
• Traditional Chinese Medicine

References

Icariin Resources
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