Icometasone
Synthetic corticosteroid
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Icometasone is a synthetic corticosteroid used in the treatment of various inflammatory and allergic conditions. It is part of the glucocorticoid class of medications, which are known for their potent anti-inflammatory and immunosuppressive properties.
Mechanism of Action[edit | edit source]
Icometasone works by binding to the glucocorticoid receptor in the cytoplasm of cells. This complex then translocates to the cell nucleus, where it binds to glucocorticoid response elements in the DNA. This binding modulates the transcription of various genes, leading to a decrease in the production of pro-inflammatory cytokines and an increase in the production of anti-inflammatory proteins.
Uses[edit | edit source]
Icometasone is primarily used to treat conditions such as asthma, allergic rhinitis, and various dermatological conditions like eczema and psoriasis. It is also used in the management of autoimmune diseases and other inflammatory conditions.
Side Effects[edit | edit source]
Common side effects of icometasone include skin thinning, bruising, and increased susceptibility to infections. Long-term use can lead to more serious side effects such as osteoporosis, adrenal suppression, and Cushing's syndrome.
Pharmacokinetics[edit | edit source]
Icometasone is typically administered via inhalation, topical application, or intranasal spray. It has a high affinity for the glucocorticoid receptor, which contributes to its potent anti-inflammatory effects. The drug is metabolized primarily in the liver and excreted via the kidneys.
Contraindications[edit | edit source]
Icometasone is contraindicated in patients with known hypersensitivity to corticosteroids. It should be used with caution in patients with tuberculosis, untreated fungal infections, and ocular herpes simplex.
See Also[edit | edit source]
References[edit | edit source]
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