Indobufen

Indobufen is a medication used primarily as an antiplatelet agent. It is a non-steroidal anti-inflammatory drug (NSAID) that inhibits the aggregation of platelets in the blood, thereby preventing blood clots from forming. Indobufen is often used in the prevention of thrombosis and embolism in patients with atrial fibrillation or following certain types of surgery.

Mechanism of Action

Indobufen works by inhibiting the enzyme cyclooxygenase, which is responsible for the production of prostaglandins and thromboxanes. By blocking the production of these substances, Indobufen prevents platelets from sticking together and forming clots.

Uses

Indobufen is used in the prevention of thrombotic events in patients with atrial fibrillation or following surgery. It is also used in the treatment of intermittent claudication, a condition characterized by pain in the legs due to inadequate blood flow.

Side Effects

Like all medications, Indobufen can cause side effects. The most common side effects include gastrointestinal symptoms such as nausea, vomiting, and diarrhea. Less common side effects can include headache, dizziness, and rash.

Contraindications

Indobufen should not be used in patients with a history of hypersensitivity to the drug or other NSAIDs. It is also contraindicated in patients with active peptic ulcer disease, severe liver disease, or severe kidney disease.

Interactions

Indobufen can interact with other medications, including other NSAIDs, anticoagulants, and certain antidepressants. It is important for patients to inform their healthcare provider of all medications they are currently taking.

See Also

• Antiplatelet drug
• Nonsteroidal anti-inflammatory drug
• Thrombosis
• Embolism

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