Inhibin alpha
Inhibin alpha is a protein that in humans is encoded by the INHA gene. It is a member of the transforming growth factor-beta (TGF-beta) superfamily, characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein.
Function[edit | edit source]
Inhibin alpha is a subunit of both inhibin and activin. Inhibins and activins inhibit and activate, respectively, the secretion of follicle-stimulating hormone (FSH) from the pituitary gland. Inhibin consists of a beta subunit and an alpha subunit, and inhibin alpha-subunit is a glycoprotein that is structurally related to the beta-subunit.
Clinical significance[edit | edit source]
Mutations in the inhibin alpha gene are associated with ovarian cancer. The inhibin alpha subunit is also known to be a tumor-suppressor gene and is important for tumor diagnosis and prognosis.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
