Interleukin 10 receptor, alpha subunit

Interleukin 10 receptor, alpha subunit (IL10RA) is a type of protein that in humans is encoded by the IL10RA gene. It is a part of the interleukin-10 receptor family, which plays a crucial role in immunology and inflammation.

Structure

The IL10RA protein is a subunit of the interleukin-10 receptor. It is a type I transmembrane protein and is expressed on the surface of certain immune cells, including T cells, B cells, and monocytes. The protein has a large extracellular domain, a single transmembrane domain, and a short cytoplasmic tail.

Function

The IL10RA protein is involved in the signal transduction pathway of interleukin 10. When interleukin 10 binds to the receptor, it triggers a signal cascade that leads to the activation of other proteins and genes involved in immune response. This can result in the suppression of inflammatory responses and the promotion of immune tolerance.

Clinical significance

Mutations in the IL10RA gene can lead to a variety of autoimmune diseases, including inflammatory bowel disease and psoriasis. These diseases are characterized by an overactive immune response, which can be caused by a lack of IL10RA function.

See also

• Interleukin 10
• Interleukin-10 receptor
• Autoimmune disease

References

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