Iproclozide
Antidepressant drug
Drug Information | |||
---|---|---|---|
Image | |||
Identifiers
ATC Code
|
Chemical Data
C H N O Molecular Weight |
Iproclozide is a monoamine oxidase inhibitor (MAOI) that was used as an antidepressant in the treatment of depression. It belongs to the class of hydrazine derivatives.
Mechanism of Action[edit | edit source]
Iproclozide works by inhibiting the activity of the enzyme monoamine oxidase (MAO). This enzyme is responsible for breaking down monoamine neurotransmitters such as serotonin, norepinephrine, and dopamine. By inhibiting MAO, iproclozide increases the levels of these neurotransmitters in the brain, which can help alleviate symptoms of depression.
Clinical Use[edit | edit source]
Iproclozide was primarily used in the treatment of major depressive disorder. However, due to the risk of severe side effects and the development of safer antidepressants, its use has declined.
Side Effects[edit | edit source]
The use of iproclozide can lead to several side effects, including:
- Hypertensive crisis (especially when taken with tyramine-rich foods)
- Orthostatic hypotension
- Insomnia
- Weight gain
- Sexual dysfunction
Interactions[edit | edit source]
Iproclozide can interact with various substances, leading to potentially dangerous effects. Notable interactions include:
- Tyramine-rich foods (e.g., aged cheese, cured meats)
- Other antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs)
- Sympathomimetic drugs
Withdrawal and Discontinuation[edit | edit source]
Abrupt discontinuation of iproclozide can lead to withdrawal symptoms, including:
History[edit | edit source]
Iproclozide was developed and introduced in the mid-20th century. It was one of the earlier MAOIs used for the treatment of depression. However, due to its side effect profile and the advent of newer antidepressants, its use has significantly decreased.
See Also[edit | edit source]
- Monoamine oxidase inhibitor
- Antidepressant
- Major depressive disorder
- Serotonin
- Norepinephrine
- Dopamine
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD