Isobutyronitrile

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Isobutyronitrile[edit | edit source]

Isobutyronitrile is an organic compound with the chemical formula (CH3)2CHCN. It is a colorless liquid that is used as a solvent and in the synthesis of some pharmaceuticals and other organic compounds.

Structure and Properties[edit | edit source]

Isobutyronitrile is a nitrile compound, which means it contains a carbon-nitrogen triple bond. The molecule is linear, with the nitrogen at one end and the isobutyl group at the other. It has a molecular weight of 69.11 g/mol and a density of 0.782 g/cm3.

The compound is a polar molecule due to the presence of the carbon-nitrogen triple bond, which creates a region of high electron density. This makes isobutyronitrile a good solvent for many organic compounds.

Synthesis[edit | edit source]

Isobutyronitrile can be synthesized by the reaction of isobutyl alcohol with ammonium chloride and sodium cyanide. The reaction is carried out in an aqueous solution and requires heat to proceed.

Uses[edit | edit source]

Isobutyronitrile is primarily used as a solvent in the chemical industry. It is also used in the synthesis of some pharmaceuticals, including antibiotics and antiviral drugs. In addition, it is used in the production of other organic compounds, such as plasticizers and resins.

Safety[edit | edit source]

Isobutyronitrile is a flammable liquid and its vapors can form explosive mixtures with air. It is also toxic if inhaled, ingested, or absorbed through the skin. Therefore, it should be handled with care and appropriate safety measures should be taken.

See Also[edit | edit source]


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Contributors: Prab R. Tumpati, MD