Isoquercetin

Isoquercetin

Chemical structure of Isoquercetin

Isoquercetin, also known as isoquercitrin, is a flavonoid compound that belongs to the class of flavonols. It is a glycoside form of quercetin, which is a naturally occurring polyphenol found in many plants. Isoquercetin is known for its potential antioxidant, anti-inflammatory, and antiviral properties.

Chemical Structure

Isoquercetin is a quercetin molecule bound to a glucose molecule. The chemical structure of isoquercetin is characterized by the attachment of a glucose moiety to the hydroxyl group at the 3-position of the quercetin backbone. This glycosidic linkage enhances the solubility of quercetin in water, making isoquercetin more bioavailable than its aglycone form.

Sources

Isoquercetin is found in various fruits, vegetables, and herbs. Common dietary sources include apples, onions, grapes, and tea. It is also present in medicinal plants such as Ginkgo biloba and Hypericum perforatum (St. John's Wort).

Biological Activities

Isoquercetin exhibits several biological activities that contribute to its potential health benefits:

Antioxidant Activity

Isoquercetin acts as an antioxidant by scavenging free radicals and reducing oxidative stress in the body. This activity helps protect cells from damage and may reduce the risk of chronic diseases such as cardiovascular disease and cancer.

Anti-inflammatory Effects

The compound has been shown to inhibit the production of pro-inflammatory cytokines and enzymes, thereby reducing inflammation in various tissues. This property makes isoquercetin a potential therapeutic agent for inflammatory conditions such as arthritis and asthma.

Antiviral Properties

Isoquercetin has demonstrated antiviral activity against several viruses, including the influenza virus and hepatitis C virus. It is believed to interfere with viral replication and enhance the immune response to infections.

Potential Health Benefits

Due to its biological activities, isoquercetin is being studied for its potential health benefits, which include:

• Reducing the risk of cardiovascular diseases by improving endothelial function and lowering blood pressure.
• Supporting immune function and enhancing resistance to infections.
• Protecting against neurodegenerative diseases by reducing neuroinflammation and oxidative damage in the brain.

Related Pages

• Quercetin
• Flavonoid
• Antioxidant
• Glycoside