JWH-366
0JWH-366 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist for the CB1 receptor and CB2 receptor. It was first identified by chemist John W. Huffman and his team at Clemson University, hence the prefix "JWH" in its name.
Chemistry[edit | edit source]
JWH-366 is a member of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073, but it has a unique chemical structure that distinguishes it from these other compounds. The molecule consists of a naphthoyl group, an indole ring, and a alkyl chain. The length and composition of the alkyl chain can vary, which can affect the potency and selectivity of the compound for the CB1 and CB2 receptors.
Pharmacology[edit | edit source]
JWH-366 acts as a potent agonist for the CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. The CB1 receptor is primarily located in the brain and is responsible for the psychoactive effects of cannabinoids. The CB2 receptor is primarily found in the immune system and is involved in immune response and inflammation.
The exact mechanism of action of JWH-366 is not fully understood, but it is believed to mimic the action of the natural cannabinoid anandamide, which is an endogenous agonist for the CB1 and CB2 receptors. Like anandamide, JWH-366 binds to these receptors and activates them, leading to a range of effects.
Effects[edit | edit source]
The effects of JWH-366 are similar to those of other synthetic cannabinoids and include euphoria, relaxation, altered perception, and in some cases, psychosis. However, due to its high potency and selectivity for the CB1 receptor, the effects of JWH-366 can be more intense and longer-lasting than those of natural cannabinoids such as THC.
Legal Status[edit | edit source]
The legal status of JWH-366 varies by country. In many countries, including the United States, it is classified as a Schedule I controlled substance, which means it is illegal to manufacture, distribute, or possess.
See Also[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
