JWH-366

JWH-366

0JWH-366 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist for the CB1 receptor and CB2 receptor. It was first identified by chemist John W. Huffman and his team at Clemson University, hence the prefix "JWH" in its name.

Chemistry

JWH-366 is a member of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073, but it has a unique chemical structure that distinguishes it from these other compounds. The molecule consists of a naphthoyl group, an indole ring, and a alkyl chain. The length and composition of the alkyl chain can vary, which can affect the potency and selectivity of the compound for the CB1 and CB2 receptors.

Pharmacology

JWH-366 acts as a potent agonist for the CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. The CB1 receptor is primarily located in the brain and is responsible for the psychoactive effects of cannabinoids. The CB2 receptor is primarily found in the immune system and is involved in immune response and inflammation.

The exact mechanism of action of JWH-366 is not fully understood, but it is believed to mimic the action of the natural cannabinoid anandamide, which is an endogenous agonist for the CB1 and CB2 receptors. Like anandamide, JWH-366 binds to these receptors and activates them, leading to a range of effects.

Effects

The effects of JWH-366 are similar to those of other synthetic cannabinoids and include euphoria, relaxation, altered perception, and in some cases, psychosis. However, due to its high potency and selectivity for the CB1 receptor, the effects of JWH-366 can be more intense and longer-lasting than those of natural cannabinoids such as THC.

Legal Status

The legal status of JWH-366 varies by country. In many countries, including the United States, it is classified as a Schedule I controlled substance, which means it is illegal to manufacture, distribute, or possess.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman

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