KLF5

KLF5, also known as Krüppel-like factor 5, is a protein that in humans is encoded by the KLF5 gene. It is a member of the Krüppel-like factor family of transcription factors.

Function

KLF5 is a transcription factor that binds directly to specific promoter regions of target genes and regulates their expression. It plays a crucial role in regulating the proliferation of epithelial cells, and is also involved in the differentiation of smooth muscle cells and the activation of inflammatory genes.

Structure

The KLF5 protein consists of three C2H2-type zinc fingers at the C-terminus, which are responsible for binding to DNA. The N-terminus contains a transcriptional activation domain.

Clinical significance

Alterations in the expression of KLF5 have been implicated in a variety of diseases, including cancer, cardiovascular disease, and diabetes. In particular, overexpression of KLF5 has been observed in several types of cancer, including breast cancer, colorectal cancer, and gastric cancer, suggesting a potential role in tumorigenesis.

Research

Research into KLF5 is ongoing, with studies investigating its role in cell proliferation, differentiation, and inflammation, as well as its potential as a therapeutic target in cancer and other diseases.

See also

• Krüppel-like factors
• Transcription factor
• Gene expression