LH-RH
Luteinizing Hormone-Releasing Hormone (LH-RH)
Luteinizing hormone-releasing hormone (LH-RH), also known as gonadotropin-releasing hormone (GnRH), is a peptide hormone responsible for the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. LH and FSH are essential for reproduction in both males and females.
Function[edit | edit source]
LH-RH is released from the hypothalamus in a pulsatile manner. This pulsatile release is crucial for its function, as continuous exposure to LH-RH results in downregulation of the LH-RH receptors in the pituitary and a decrease in LH and FSH secretion.
In females, LH and FSH stimulate the ovaries to produce estrogen and progesterone, and are involved in the regulation of the menstrual cycle and ovulation. In males, LH stimulates the testes to produce testosterone, while FSH stimulates sperm production.
Clinical significance[edit | edit source]
LH-RH analogs and antagonists are used in the treatment of various endocrine disorders, including prostate cancer, breast cancer, endometriosis, and precocious puberty. These drugs work by modulating the release of LH and FSH from the pituitary.
See also[edit | edit source]
- Luteinizing hormone
- Follicle-stimulating hormone
- Gonadotropin-releasing hormone
- Hypothalamus
- Anterior pituitary
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Contributors: Prab R. Tumpati, MD
