LPAR2
LPAR2 or Lysophosphatidic Acid Receptor 2 is a protein that in humans is encoded by the LPAR2 gene. It is a member of the G protein-coupled receptor family and plays a crucial role in several biological processes, including cell proliferation, cell differentiation, and apoptosis.
Function[edit | edit source]
LPAR2 is a receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. It seems to be coupled to the G protein G(i) and G(q). LPA is an extracellular signaling molecule that has been implicated in various biological processes, including cell migration, cell growth, and cell survival.
Clinical Significance[edit | edit source]
Alterations in LPAR2 have been associated with various diseases, including cancer, fibrosis, inflammation, and neuropathic pain. In cancer, overexpression of LPAR2 has been observed in several types of tumors, suggesting a role in tumor progression.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
