LY 215840

LY 215840 is a chemical compound that is often used in biomedical research. It is a potent and selective serotonin 5-HT2A receptor antagonist. This compound has been used in various studies to understand the role of 5-HT2A receptors in the brain and their potential implications in various neurological disorders.

Chemical Structure

LY 215840 is a dihydrobenzofuran derivative. Its chemical structure is characterized by a dihydrobenzofuran core, which is substituted at the 5-position with a phenyl group. The phenyl group is further substituted at the 4-position with a piperazine ring. The piperazine ring is substituted at one of its nitrogen atoms with a propyl chain.

Pharmacology

LY 215840 acts as a potent and selective antagonist at the 5-HT2A receptor. The 5-HT2A receptor is one of the several different subtypes of the 5-HT2 receptor that are found in the central nervous system. These receptors are involved in a variety of physiological functions, including the regulation of mood and cognition, as well as the modulation of the immune system.

Clinical Implications

The selective antagonism of the 5-HT2A receptor by LY 215840 has potential implications in the treatment of various neurological disorders. For instance, the 5-HT2A receptor has been implicated in the pathophysiology of schizophrenia, and LY 215840 may therefore have potential as an antipsychotic drug. Similarly, the 5-HT2A receptor is also involved in the regulation of mood and anxiety, suggesting that LY 215840 may have potential in the treatment of mood disorders and anxiety disorders.

Research Use

LY 215840 is widely used in biomedical research to study the role of the 5-HT2A receptor in the brain. It is often used in animal models to induce a state of 5-HT2A receptor antagonism, allowing researchers to investigate the effects of this state on various physiological and behavioral parameters.

See Also

• 5-HT2A receptor
• Serotonin
• Neurological disorders
• Schizophrenia
• Anxiety disorders