Lipoatrophic diabetes

Lipoatrophic diabetes (also known as Lawrence Syndrome) is a rare form of diabetes characterized by the loss of adipose tissue, insulin resistance, and hypertriglyceridemia. This condition is also associated with hepatomegaly and acanthosis nigricans.

Symptoms

The symptoms of lipoatrophic diabetes include:

• Loss of subcutaneous fat
• Hyperglycemia
• Hypertriglyceridemia
• Hepatomegaly
• Acanthosis nigricans

Causes

The exact cause of lipoatrophic diabetes is unknown. However, it is believed to be associated with autoimmune diseases, infections, and genetic disorders.

Diagnosis

Diagnosis of lipoatrophic diabetes is based on clinical features, laboratory tests, and imaging studies. Laboratory tests may include blood glucose levels, lipid profile, and liver function tests. Imaging studies may include ultrasound of the liver and magnetic resonance imaging (MRI) of the abdomen.

Treatment

Treatment of lipoatrophic diabetes involves managing the symptoms and preventing complications. This may include insulin therapy, dietary modifications, and exercise. In severe cases, liposuction or fat transplantation may be considered.

See also

• Diabetes mellitus
• Lipodystrophy
• Insulin resistance

References

Lipoatrophic diabetes Resources
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