Liquid chromatography–mass spectrometry

Liquid chromatography–mass spectrometry (LC-MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS).

Overview

LC-MS is a powerful technique used for many applications which has very high sensitivity and selectivity. Generally its application is oriented towards the general detection and potential identification of chemicals in the presence of other chemicals (in a complex mixture).

Principle

LC-MS system is divided into three parts. The LC module, the MS module and the computer system.

Applications

LC-MS is widely used in the field of bioanalysis and is specially involved in pharmacokinetic studies of pharmaceuticals. It is also extensively used in the metabolomics and proteomics.

See also

• Gas chromatography–mass spectrometry
• Capillary electrophoresis–mass spectrometry
• Ion mobility spectrometry–mass spectrometry
• Liquid chromatography–mass spectrometry

References

Liquid chromatography–mass spectrometry Resources
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