Lobeglitazone

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Lobeglitazone is a medication used for the treatment of Type 2 diabetes. It belongs to the class of drugs known as thiazolidinediones, which are oral anti-diabetic agents that act primarily by increasing insulin sensitivity. Lobeglitazone was developed by Chong Kun Dang, a South Korean pharmaceutical company.

Mechanism of Action[edit | edit source]

Lobeglitazone works by binding to the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ. This binding results in the transcription of genes involved in glucose and lipid metabolism, leading to improved insulin sensitivity and lower blood glucose levels.

Clinical Use[edit | edit source]

Lobeglitazone is used in the treatment of type 2 diabetes, particularly in patients who have not achieved adequate glycemic control with diet and exercise alone. It can be used as monotherapy or in combination with other anti-diabetic agents.

Side Effects[edit | edit source]

Like other thiazolidinediones, lobeglitazone may cause side effects such as weight gain, edema, and an increased risk of heart failure. It may also increase the risk of bone fractures in women.

See Also[edit | edit source]


Lobeglitazone Resources

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