MAP3K15

MAP3K15 (Mitogen-Activated Protein Kinase Kinase Kinase 15) is a protein that in humans is encoded by the MAP3K15 gene. This protein is part of the MAPK/ERK pathway, which is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.

Function

The MAP3K15 protein is a member of the serine/threonine protein kinase family. This kinase is known to play a critical role in mitotic cell cycle progression and DNA damage response. When activated, it initiates a cascade of phosphorylation events that are crucial for cell cycle progression and prevention of DNA replication errors.

Clinical Significance

Alterations in the MAP3K15 gene have been associated with various human diseases, including cancer. In particular, mutations in this gene have been found in a variety of cancers, suggesting that it may act as a tumor suppressor gene. Further research is needed to fully understand the role of MAP3K15 in human disease.

See Also

• Mitogen-Activated Protein Kinase
• Serine/Threonine Protein Kinase
• MAPK/ERK pathway