MODY 2

MODY 2 or Maturity Onset Diabetes of the Young Type 2 is a form of diabetes that is often misdiagnosed as Type 1 diabetes or Type 2 diabetes. It is a monogenic form of diabetes that is characterized by an early onset, usually before the age of 25, and is non-insulin dependent.

Causes[edit | edit source]

MODY 2 is caused by mutations in the GCK gene. This gene provides instructions for making an enzyme called glucokinase, which plays a key role in regulating blood sugar levels. Mutations in the GCK gene reduce the activity of glucokinase, disrupting the regulation of blood sugar levels and leading to the characteristic features of MODY 2.

Symptoms[edit | edit source]

The symptoms of MODY 2 are similar to those of other forms of diabetes, including frequent urination, excessive thirst, fatigue, and blurred vision. However, people with MODY 2 often have mild, stable, fasting hyperglycemia and do not require insulin treatment.

Diagnosis[edit | edit source]

Diagnosis of MODY 2 is based on clinical features, family history, and genetic testing. Genetic testing is the only definitive way to diagnose MODY 2 and can help differentiate it from other forms of diabetes.

Treatment[edit | edit source]

Treatment for MODY 2 typically involves lifestyle modifications such as diet and exercise. Some people may require medication to manage their blood sugar levels, but insulin is not typically required.

Prognosis[edit | edit source]

The prognosis for people with MODY 2 is generally good. With proper management, people with MODY 2 can lead normal, healthy lives.

See also[edit | edit source]

MODY 2 Resources
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