MOGAT3

MOGAT3 or Monoacylglycerol O-acyltransferase 3 is an enzyme that in humans is encoded by the MOGAT3 gene. This enzyme is part of the monoacylglycerol O-acyltransferase family and plays a crucial role in lipid metabolism.

Function

MOGAT3 is involved in the biosynthesis of triglycerides. It catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The enzyme is found in the endoplasmic reticulum, where it contributes to the production of lipids for membrane biosynthesis and lipid droplets.

Clinical Significance

Alterations in the MOGAT3 gene have been associated with obesity and type 2 diabetes. Studies have shown that overexpression of MOGAT3 in mice leads to increased adiposity, insulin resistance, and impaired glucose tolerance. Conversely, MOGAT3 knockout mice have reduced adiposity and improved insulin sensitivity.

See Also

• MOGAT1
• MOGAT2
• Acyl-CoA
• Diacylglycerol