MPGES-2

Microsomal Prostaglandin E Synthase-2 (MPGES-2) is an enzyme that in humans is encoded by the PTGES2 gene. It is a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family.

Function

MPGES-2 is an enzyme involved in the prostaglandin biosynthetic pathway. It catalyzes the conversion of prostaglandin H2 to prostaglandin E2 (PGE2). PGE2 is a potent inflammatory mediator that plays a crucial role in the onset and progression of several diseases, including cancer, rheumatoid arthritis, and neurodegenerative diseases.

Structure

MPGES-2 is a membrane protein that is localized in the endoplasmic reticulum and the nuclear envelope. It consists of four transmembrane domains and has a catalytic site facing the lumen of the endoplasmic reticulum.

Clinical significance

Due to its role in the production of PGE2, MPGES-2 is a potential target for the development of anti-inflammatory drugs. Inhibition of MPGES-2 could potentially reduce the production of PGE2 and thereby alleviate the symptoms of diseases associated with inflammation.

See also

• Prostaglandin-endoperoxide synthase
• Prostaglandin E synthase
• Prostaglandin

References

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