Mabel Hokin

American biochemist

Mabel R. Hokin, biochemist

Mabel Ruth Hokin (née Neaverson; October 10, 1924 – December 12, 2003) was an American biochemist renowned for her pioneering work in the field of phospholipid metabolism and signal transduction. Her research significantly advanced the understanding of cellular processes and laid the groundwork for future studies in cell biology and biochemistry.

Early Life and Education

Mabel Hokin was born in Sioux City, Iowa, and developed an early interest in science. She pursued her undergraduate studies at the University of Chicago, where she earned a Bachelor of Science degree in 1945. She continued her education at the same institution, obtaining a Ph.D. in biochemistry in 1950. Her doctoral research focused on the enzymatic processes involved in cellular metabolism.

Career and Research

Hokin's career was marked by her groundbreaking discovery of the phosphoinositide cycle, a crucial pathway in cellular signaling. In collaboration with her husband, Lowell Hokin, she demonstrated that the stimulation of certain cells led to the rapid turnover of phospholipids, particularly phosphoinositides. This work was pivotal in understanding how cells respond to external signals and communicate internally.

Phosphoinositide Cycle

The discovery of the phosphoinositide cycle was a major advancement in the field of cell signaling. Hokin's research showed that the breakdown of phosphoinositides was linked to the activation of protein kinase C, an enzyme that plays a key role in various cellular functions, including cell growth, differentiation, and apoptosis. This pathway is now known to be involved in numerous physiological processes and is a target for therapeutic interventions in diseases such as cancer and diabetes.

Academic Contributions

Throughout her career, Hokin published extensively in scientific journals, contributing to the broader understanding of lipid metabolism and signal transduction. She was a dedicated mentor to many students and young scientists, fostering a collaborative and innovative research environment.

Legacy

Mabel Hokin's work has had a lasting impact on the field of biochemistry. Her discoveries have provided a foundation for subsequent research into cellular signaling mechanisms and have influenced the development of new therapeutic strategies. Her contributions to science have been recognized by her peers, and she remains a respected figure in the scientific community.

Personal Life

Mabel Hokin was married to Lowell Hokin, with whom she frequently collaborated on research projects. Together, they were a formidable team in the field of biochemistry. Outside of her scientific pursuits, Hokin was known for her passion for education and her commitment to advancing the role of women in science.

Related Pages

• Phosphoinositide
• Signal transduction
• Protein kinase C
• Cell biology